UCLA Bioinformatics Program

Speaker: Ernest Frankel, Department of Biological Engineering,
Massachusetts Institute of Technology.
Title: Bridging the Gap Between High-Throughput Genetic and Transcrptional Data Reveals Cellular Pathways Repsonding to Alph-Synuclein Toxicity.

When: Mon., January 26, 2009 4PM
Where: CNSI Auditorium
Where: CNSI Auditorium

Abstract

Efforts to identify the mechanisms of cellular responses to perturbations
increasingly depend on high-throughput data including mRNA profiling and
genetic library screens. Yet the functional roles of the genes identified
by these assays often remain enigmatic. By comparing the results of these
two assays across various cellular responses, we found that they are
consistently distinct. Moreover, genetic screens tend to identify
response regulators, while mRNA profiling frequently detects metabolic
responses. We developed an integrative approach that bridges the gap
between these data using known molecular interactions, highlighting major
response pathways. We harnessed this approach to reveal cellular pathways
related to alpha-synuclein, a small lipid-binding protein implicated in
several neurodegenerative disorders including Parkinson disease.

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