UCLA Bioinformatics Program

Speaker: Eugene Myers, Janelia Farm Research Campus, HHMI

When: Mon, May 5, 2008

Where: CNSI Auditorium

Abstract:
Our group is developing algorithms and software for the automatic interpretation of images produced by light and electron microscopy of stained samples with a particular emphasis on building 3D and 4D “atlases” of brains, developing organisms, and cellular processes. Specific project include (a) the in vivo monitoring of mitotic processes in a developing C. elegans embryo (with T. Hyman, MPI-CBG, Dresden), (b) the in situ observation of C. elegans’ cells in stages L1 through adult to decode their transcriptional and functional states (with S. Kim, Stanford), (c) the detailed neuro-anatomy of an entire fly brain including all synaptic connections via a hybrid approach combining EM and light-microscopy (with colleagues at Janelia), and (d) mapping the developmental trajectory of the fly brain via the visual analysis of MARCM clones and promotor fusions (with V. Hartenstein, UCLA, G. Rubin, J. Simpson, and J. Truman, JFRC).

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