UCLA Bioinformatics Program

Speaker: Martha Bulyk, Dept. of Medicine, Pathology, and Health Sciences & Technology (HST), Brigham & Women’s Hospital and Harvard Medical School

When: Mon, April 28, 2008

Where: CNSI Auditorium

Abstract:
The interactions between transcription factors (TFs) and their DNA binding sites are an integral part of the cellular regulatory networks that control gene expression. We have developed in vitro protein binding microarray (PBM) technologies for the rapid, high-throughput characterization of the DNA binding site sequence specificities of TFs. Recently we have applied the PBM technology to study a large number of known and predicted TFs from various organisms, including yeast, fly, and mouse. We are now using PBM data on the DNA binding specificities of metazoan TFs to more accurately derive cis regulatory codes in these large genomes. Specifically, we are inferring co-regulation by sets of TFs through an integrated analysis of gene expression data, TF binding site motif data, and prediction of cis regulatory modules.

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